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Fresenius F6 HPS Dialyzer, For Haemodialysis
Fresenius F6 HPS Dialyzer, For Haemodialysis - Image 2
Fresenius F6 HPS Dialyzer, For Haemodialysis - Image 3
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Fresenius F6 HPS Dialyzer, For Haemodialysis

F-Series

Not all polysulfones are like Fresenius

Polysulfone

  • Proven quality and efficiency of Fresenius Polysulfone
  • The original benchmark for biocompatibility
  • INLINE steam sterilized
  • Available in both low-flux and high-flux ranges
csm_SPE001_F-Series_8f57fa749b

Key features

Fresenius Polysulfone® — A synonym for biocompatibility

  • Adverse interactions between blood and material arising during the dialysis treatment have been related to a variety of clinical symptoms
  • It has become increasingly evident that not all dialysis membranes are the same with respect to their ability to activate blood cell components1
  • Ever since its introduction, Fresenius Polysulfone® has been recognized for its biocompatibility and was an established benchmark for all membrane improvements and developments 2,3,4,5 

Safety during each and every treatment

  • All Fresenius Medical Care dialyzers provide a high degree of safety during each and every treatment
  • The high endotoxin retention capabilities of the Fresenius Polysulfone® are attributed to the chemical composition and structure of the membrane

Enhanced design for maximum efficiency

  • The special undulating structure of the hollow fibers delivers an excellent performance profile
  • Spacing between the wavy fiber structures keeps the individual fibers apart, preventing dialyzate channeling and facilitating a uniform flow of dialyzate within the fiber bundle
  • The consistent dialyzate flow around each fiber ensures every single performs at maximum efficiency, resulting in enhanced solute transport
The endotoxin permeability profiles of different synthetic low-flux membranes6
The endotoxin permeability profiles of different synthetic low-flux membranes6
The wavy structure of the hollow fibres reduces dialysate channelling and enhances solute transport.
The wavy structure of the hollow fibres reduces dialysate channelling and enhances solute transport. 

Technology

INLINE steam sterilization – purity enhanced

No chemical residuals. Low rinsing volumes. Lower costs.

INLINE steam
The INLINE steam sterilization process of F-Series dialyzers. Diagram shows example use with FX dialyzers.

INLINE steam sterilization – how it works

  1. Both the blood and the dialysate compartment of the dialyzers are rinsed continuously with steam at a temperature at or above 121°C for a minimum of 15 minutes. Rinsing with hot steam and without chemicals results in extremely low levels of residuals in the dialyzer
  2. The dialyzer is rinsed with sterile water
  3. Every dialyzer is tested for fiber integrity using a bubble-point test
  4. The dialyzers are dried with warm, sterile air
  5. Finally, after drying the blood inlet and outlet ports are closed

INLINE steam sterilization – the benefits

  • Highly pure, sterile and pyrogen-free dialyzers without any potentially harmful residuals from sterilization
  • Biocompatibility of membranes remains unaffected from sterilization
  • Optimized use of resources due to low rinsing volumes: only 500 mL is required
  • Dry dialyzers with minimized risk of contamination due to microbial growth

Fibre integrity testing

  • All dialyzers have to pass the bubble point test as part of the INLINE steam sterilization process
  • Sterile air is pressed into the dialyzate compartment while the blood compartment contains sterile water
  • If any leakages were present in the membrane, air would pass through the membrane and create bubbles
  • Dialyzers failing the integrity test are discarded
  • This integrity test minimizes the risk of fibre ruptures and the risk of blood leakages

Quality from start to finish

  • Fresenius Polysulfone® dialyzers are produced to meet international safety regulations
  • Fresenius Medical Care’s core competency is the complete production from membranes to the finished dialyzers, providing the highest quality during every step of production 
Quality from start to finish

Performance data

Low Flux Dialysers – High Performance Steam (HPS)

Low Flux Dialysers – High Performance Steam (HPS) F4 HPS  F5 HPS  F6 HPS  F7 HPS F8 HPS   F10 HPS
Ultrafiltration coefficient (ml/h x mmHg) 8 10 13 16 18 21
Clearance: QB: (200ml/min)
Urea 170 179 186 188
Creatinine 149 162 173 175
Phosphate 123 139 148 155
Vitamin B12 75 84 92 102
Clearance: QB: (300ml/min) 
Urea 227 243 247 252 259
Creatinine 196 215 220 224 230
Phosphate 162 175 186 193 208
Vitamin B12 91 100 113 118 131
Clearance: QB: (400ml/min) 
Urea 290 300
Creatinine 251 259
Phosphate 212 231
Vitamin B12 124 139
The in vitro performance data were obtained with QD = 500ml/min:
QF = 0ml/min; T=37°C (ISO8637)
The ultrafiltration coefficients were maintained using human blood,
Hct = 32%, protein content 6%
Effective surface area (m²) 0.8 1.0 1.3 1.6 1.8 2.2
Blood priming volume (ml) 51 63 78 96 113 132
Membrane material Fresenius Polysulfone®
Housing material Polycarbonate
Potting compound Polyurethane
Sterilization method Inline Steam
Form of treatment HD
Art. No. 5007041 5007051 5007061 5007071 5007081 5007201
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Fresenius F6 HPS Dialyzer

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